Inhaled medicines have the following effect:
- Promote hydration
- Reduce secretion viscosity
- Optimize mucociliary clearance
PEP therapy has the following effect:
Improve collateral ventilation to allow better distribution of gas beyond occluded airwaysPEP works by creating a positive pressure to splint open and stabilize airways, preventing bronchial collapse. So when a treatment is given in conjunction with a nebulizer, it may result in better distribution of the medicine while enhancing secretion clearance.
- Mesquita, Fabricio, et al., "Scintigraphic Assessment of radio-Aerosol Pulmonary Deposition With the Acapella Positive Expiratory Pressure Device and Varoius Nebulizer Configurations," Respiratory Care, March, 2014, volume 59, number 3, pages 328-333
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